TOXICITY | Heavy Metals | Xenoestrogens + Neurological | BIG
"JOINCIRCLES enables you to own your own medical data. After buying an advanced biochemistry test here, we’ll send your test kit out the next working day. When your kit arrives, do the test and call our courier to collect – follow the simple instructions in the kit. The lab will take around 21 working days to analyse your sample from the time they receive your sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They may suggest additional relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your biochemistry results, you can start shopping for your personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | firstname.lastname@example.org
Heavy metals that can cause neurological problems
We're all exposed to different amounts of essential and toxic elements depending on where we live, our nutrition, environment and our lifestyle choices.
The levels of both essential and toxic elements that we consume, or that we are exposed to from the environment, are determined by where we live, the water we drink, the supplements we take, and the levels in soil/irrigation water used to grow the foods we eat. We are also exposed to toxic elements through environmental pollution of the air we breathe, as well as exposure through our skin.
How do different levels of essential and toxic elements aspect health? Essential elements are only conducive to optimal health when they are within optimal ranges. Levels that are too low or too high can have detrimental effects on health. Therefore, it is important to know if essential or toxic elements are outside their optimal ranges.
Both iodine and selenium are good examples of essential elements that can be both beneficial and toxic, depending on their levels. Severe iodine deficiency and extreme excesses cause thyroid deficiency and goitre. The same is true for selenium. A severe deficiency impairs the enzymes necessary for anti-oxidant actions and thyroid deiodinases that convert inert T4 to bioactive T3. In contrast, an excess of selenium can cause death.
Bromine is in the same chemical family as iodine and excessive amounts will compete with iodine in the thyroid. This becomes particularly problematic when iodine levels are borderline low, or lower, and bromine is high.
Copper and zinc are essential micronutrients that are needed in very small quantities in the diet but are toxic at concentrations greater than is necessary for their biological functions. Magnesium is an essential element with a significant role in cellular metabolism and protein synthesis, and its deficiency causes problems from muscle weakness to cardiac arrhythmias.
Arsenic, mercury, cadmium, and lead are toxic heavy metals with no known nutritional bene ts in the human body. High levels of them lead to an increase in Reactive Oxygen Species (ROS) that damage proteins, lipids, and DNA. They also form tight bonds with essential elements such as selenium, reducing its bioavailability for enzymes such as glutathione peroxidase and thyroid deiodinase, both essential for thyroid hormone synthesis and activation. Arsenic, mercury, lead, and cadmium are extremely hazardous to human health. They represent the top four most toxic heavy metals according to the CDC’s priority list of hazardous substances1. Lead, mercury, and cadmium accumulate and are retained in the body, and so their toxic effects are cumulative and more pronounced with ageing.
Very little lead is excreted in urine, but it is readily taken up by red blood cells where it forms a tight complex with haemoglobin. For this reason, whole blood, and not serum or urine, is used to monitor exposure to lead. Arsenic is only measured in urine and is not included in the blood spot proem because it is rapidly cleared from the bloodstream after exposure, and would therefore only be detected in blood if testing was done immediately after exposure.
In summary, testing for these elements provides an excellent assessment of overall body burden of toxic elements and is an indicator of excessive or inadequate supplementation with nutritionally essential elements.
This test measures non-essential (heavy metals) elements and essential elements in blood and in dried urine.
Heavy metals are all around us. Common sources of heavy metal exposure include fish, seafood, rice, well water, vaccinations and dental fillings. These toxic elements can significantly increase our risk of developing conditions like dementia, infertility, diabetes and cancer. They are also known to cause damage to the liver, kidneys and brain, as well as the cardiovascular, nervous and endocrine systems.
Essential elements are abundant, too, and only healthy when they are within optimal ranges. These elements, such as iodine and selenium, are critical for enzymes that synthesize neurotransmitters and activate hormones. Getting too much, and sometimes too little, of various elements has consequences for our overall health.
Who would benefit from this test?
- Is exposed to heavy metals through hobbies, work or dentistry
- Lives in an older home or an area where metals may be present in drinking water
- Has thyroid-related health issues
- Has been diagnosed with estrogen-positive breast cancer and wants to explore xenoestrogen toxicity
Benefits | Features
- Simple urine collection
- Simple finger prick
- Simple to do at home
- Easy to do yourself
- Test is applicable for all ages
- Highly accurate results
"The heavy metals in this test have also been shown to act as xenoestrogens in the body. This test is therefore ideal to do after a diagnosis of estrogen-positive breast cancer where you want to explore various reasons for estrogen excess or dominance. In this case, I would suggest starting with a DNA | Estrogen test, or one of our DNA combo tests that includes our DNA | Estrogen test, plus one of our HORMONES | Hormones & Hormone Metabolites tests. Once you have these results, then only would I advise that you do this test. Please contact me if you have any questions."
Endocrine disruptors are chemicals that mimic our own hormones, in particular, estrogen. These chemicals are called 'xenoestrogens' – ‘xeno’ means ‘foreign’ or ‘from the outside’.
Xenoestrogens weakly bind to estrogen receptors and block our thyroid hormone action, and negatively affect our endocrine, nervous and immune systems.
Endocrine disruptors are found in many plastics, conventional body products and fertilizers. You could be exposed to them if you use conventional body products, drink water from plastic bottles, eat fast food in polystyrene containers, and if you eat non-organic fruit and vegetables that have been sprayed with pesticides.
Heavy metals (non-essential elements):
Bloodspot: Hg, Cd, Pb, Zn, Cu, Se & Mg
Dried urine: I, Br, Se, As, Cd & Hg
- Dried blood spot sample - only requires a shallow finger prick.
- Dried urine
Average processing time
- Approximately 3 weeks
- This test is sent to the USA
Lab's name for test
Comprehensive Elements Profile – Hg, Cd, Pb, Zn, Cu, Se & Mg (Blood Spot); I, Br, Se, As, Cd & Hg (Dried Urine)
- All tests performed at this laboratory are done to high standards of accuracy
- This lab uses state-of-the-art methodology
- All tests are validated with internal and/or external controls