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NUTRITION | Organic Acids | BIG


R 6,350.00

"JOINCIRCLES enables you to own your own medical data. After buying an advanced biochemistry test here, we’ll send your test kit out the next working day. When your kit arrives, do the test and call our courier to collect – follow the simple instructions in the kit. The lab will take around 21 working days to analyse your sample from the time they receive your sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They may suggest additional relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your biochemistry results, you can start shopping for your personalised nutrition, environment and lifestyle choices on This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi |

This Organic Acids | BIG test is a very comprehensive nutritional test that provides insights into your body's organic acids and cellular metabolic processes.

How is this test different?

This test is different to other food allergy or food sensitivity tests. It's also different to tests that show actual nutrient levels, for example, your magnesium levels. Instead, this test shows specific nutrient levels indirectly, in addition to much more. It shows how your body is breaking down your nutrients through your unique biochemistry. This is a far more comprehensive view and it can measure your genetic expression more accurately. 

For example, instead of just showing that you are deficient in a nutrient, this test also shows whether the reason for the deficiency is due to a genetic variation that is not allowing a nutrient to be 'activated' into its most useful form. Instead of just showing you are low in an antioxidant, this test will show your oxidative stress levels. 

Thus, this test is great to pair with our DNA | Health test - to check how your genetic potential is manifesting in real-time. This test enables you to measure and track many of your nutrition, environment, and lifestyle choices.

More info

Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit (a misspelling from your DNA), toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.

A full review of your biochemical status and metabolic pathway flow can help identify areas of greatest concern. Follow-up nutritional testing can monitor the effectiveness of selected treatments. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions and lead to improved outcomes.

Our Comments

"This test gets right down into your body's biochemistry and helps you to identify your cellular metabolic blocks and key nutrient deficiencies. This test pairs very nicely with our DNA | Health. This extensive test shows how your genetic potential for disease, at a biochemical level, is manifesting in real-time according to your nutrition, environment, and lifestyle choices. Using the test's results, you and your doctor will be better able to create a personalised nutrition treatment plan for you. Please ensure your doctor knows how to interpret the test results otherwise ask us to suggest a doctor who can".

Dr. Heidi

Benefits | Features

  • Children: This test is a simple over night urine test so children can also do it. Thus, this test also has children's reference ranges, designed to provide more accurate pediatric nutritional evaluations. 
  • Innovative Method: The LC/MS-MS method, which is also used to screen newborns for metabolic disorders, requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.
  • Extensive Analyte List: The JOINCIRCLES Organic Acids | BIG test is a nutritional test which contains one of the most extensive biomarker lists in the industry. It includes nutritional markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine and thus offers great value.
  • Single Urine Specimen: A single overnight urine collection makes this test very easy to do! 

Who would benefit from this test?

    Anyone who would like to determine one or more of the following:

    • Functional vitamin and mineral status
    • Amino acid insufficiencies like carnitine and NAC
    • Functional B-complex vitamin need
    • Lipoic acid and CoQ10 status
    • Mitochondrial energy production
    • Markers for bacterial and yeast overgrowth
    • Methylation sufficiency
    • Neurotransmitter metabolites
    • Oxidative damage and antioxidant need
    • Phase I & Phase II detoxification capacity

    Anyone who suffers from:

    • Weight issues
    • Sleep abnormalities
    • Depression
    • Chemical sensitivities
    • Wants to measure and track their nutrigenomic expression in real-time

    Pair with these DNA Tests

    DNA| Health

    DNA | Estrogen

    DNA | Diet

    Urine Hormone Metabolites test

    Amino Acids 20 test

    Comprehensive Stool Analysis + Parasitology

    GI Map

    Tests for

    Organic acids levels in urine resulting from normal metabolic processes in the body.

      Test analytes

      3,4 Dihydroxyphenylpropionate

      More info about the analytes

      Fatty acid metabolism: 

      • Adipate
      • Suberate
      • Ethylmalonate

      Carbohydrate metabolism:

      • Pyruvate
      • L-Lactate
      • Beta-hydroxybutyrate

      Energy production (citric acid cycle): 

      • Citrate
      • cis-Aconitate
      • Isocitrate
      • Alpha-ketoglutarate
      • Succinate
      • Fumarate
      • Malate
      • Hydroxymethylglutarate

      B-complex vitamin markers:

      • Alpha-ketoisovalerate
      • Alpha-ketoisocaproate
      • Alpha-keto-beta-methylvalerate
      • Xanthurenate-beta-hydroxyisovalerate

      Methylation cofactor markers:

      • Methylmalonate
      • Formiminoglutamate

      Neurotransmitter metabolism markers:

      • Vanilmandelate
      • Homvanillate
      • 5-hydroxyindoleacetate
      • Kynurenate
      • Quinolinate
      • Picolinate

      Oxidative damage and antioxidant markers:

      • p-Hydroxyphenyllactate
      • 8-Hydroxy-2'-deoxyguanosine

      Detoxification indicators:

      • 2-Methylhippurate
      • Orotate
      • Glucarate
      • Alpha-Hydroxybutyrate
      • Pyroglutamate
      • Sulfate

      Bacterial – general:

      • Benzoate
      • Hippurate
      • Phenylacetate
      • Phenylpropionate
      • p-Hydroxybenzoate
      • p-Hydroxyphenylacetate
      • Indican
      • Tricarballylate


      • D-Lactate

      Clostridial species:

      • 3,4 Dihydroxyphenylpropionate

      Test sample report

      Test sample type

      Overnight urine, 12 ml, frozen

      Processing time

      About 2 weeks

      Lab's name for test

      Organix® Comprehensive Profile

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