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HORMONES | Hormones & Hormone Metabolites | Medium


R 6,142.00

"JOINCIRCLES enables you to own your own medical data. After buying an advanced biochemistry test here, we’ll send your test kit out the next working day. When your kit arrives, do the test and call our courier to collect – follow the simple instructions in the kit. The lab will take around 21 working days to analyse your sample from the time they receive your sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They may suggest additional relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your biochemistry results, you can start shopping for your personalised nutrition, environment and lifestyle choices on This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi |

Estrogens & main metabolites | Progesterones | Androgens | Testosterones | BPA | 4 x Cortisol + metabolites | 1 x Melatonin

This test is great if, along with your sex hormones, estrogen metabolites and BPA levels, you'd like to measure and track the relationship between your stress and sleep hormones.

This test also measures cortisol (stress hormone) across the day and melatonin (sleep hormone) on waking. This is to measure stress and lack of proper sleep because these play a huge part in the development of many lifestyle-related chronic diseases. 

We believe that knowing your hormone metabolites, alongside your hormones, is highly valuable in lifestyle-related chronic disease prevention, especially estrogen-positive breast cancers. 

We found one of the most niche, accurate and highly specialised hormone labs in the world and love that the founder of the lab, Dr David Zava, has specialised in hormone testing for over 40 years and has a special interest in breast cancer.  

              Why is estrogen important?

              Many man-made chemicals have been shown to have an estrogen-like effect in your body. They are called xenoestrogens; 'xeno' meaning 'from the outside' or 'foreign'. It's sad, but our planet is estrogen-ising!

              As more of these chemicals enter our environment daily, it's hard to avoid exposure. These chemicals build up in our bodies and can contribute to estrogen excess and estrogen dominance (over progesterone). 

              The number of new cases of hormone cancers, estrogen cancers, hormone cancers at younger ages, and hormone cancers with no family history, is at an all-time high. Most breast cancer cases are estrogen-positive, then progesterone.

              Only 5-10% of breast cancers are due to the BRCA (Breast Cancer) 1 & 2 gene mutation.

              Research shows that the other 70-80% of breast cancer cases are due to the interaction between our nutrition, environment and lifestyle choices and our genes. This interaction can cause, among other things, estrogen excess, estrogen dominance (over progesterone), oxidative stress, inflammation, and the production of harmful hormone metabolites.

              Of this 70-80%, most of these breast cancers are estrogen positive - meaning their growth is driven by estrogen. 

              Breast cancer is the second most prevalent female cancer. Half the world’s population is female. We really need to start preventing breast cancer earlier, using methods other than/in addition to just traditional scans like ultrasounds, mammograms and MRI's.

              Why are estrogen metabolites important?

              Doing this test allows you to measure your estrogen levels, your estrogen:progesterone ratio, and your estrogen metabolite ratios.

              As your hormones are broken down, they form breakdown products called 'hormone metabolites'. Some hormone metabolites are safe and can protect against cancer. Other hormone metabolites are dangerous because they can damage DNA and, over time, potentially initiate cancer. 

              An estrogen metabolite called 4-hydroxy estradiol is capable of causing the most damage to DNA. It is vital that this metabolite is measured, tracked, kept within safe levels and neutralised as much as possible.

              Specific nutrition, environment and lifestyle choices can help neutralise this metabolite. Pair this test with our DNA | Estrogen test to further personalise your choices.  

              Symptoms of estrogen excess & dominance 

              'Estrogen excess' is when you have a normal progesterone level but a raised estrogen level.

              'Estrogen dominance' is when you have more estrogen than progesterone. You might have normal estrogen but low progesterone due to, for example, stress or skipping/lack of ovulation.

              Estrogen dominance has also been linked to allergies, autoimmune disorders, breast cancer, uterine cancer, infertility, ovarian cysts, and increased blood clotting, and is also associated with acceleration of the ageing process.

              Estrogen excess and dominance are caused or exacerbated by the stress of all kinds.

              Many women in their thirties and early forties find that they experience moderate to severe symptoms of estrogen dominance as they approach perimenopause.

              The symptoms listed below, as well as many others, often arise when estrogen overstimulates both the brain and body:

              • Irregular or otherwise abnormal menstrual periods
              • Bloating (water retention)
              • Breast swelling and tenderness
              • Decreased sex drive
              • Fibrocystic breasts
              • Headaches (especially premenstrually)
              • Mood swings (most often irritability and depression)
              • PMS
              • Weight and/or fat gain (particularly around the abdomen and hips)
              • Thyroid dysfunction
              • Cold hands and feet (a symptom of thyroid dysfunction)
              • Hair loss
              • Sluggish metabolism
              • Foggy thinking, memory loss
              • Fatigue
              • Trouble sleeping/insomnia

              - See more at Christiane Northrup, M.D.

              Why can this test be preventative?

              This test doesn’t look for cancer markers in your blood - by then, you already have cancer. It shows imbalances in your estrogen detox biochemistry long before you start might start experiencing signs of estrogen excess, estrogen dominance, or detect an estrogen cancer. 

              These imbalances can start when you're young and only ‘tip’ into cancer when you're older (as we learnt the hard way!). That's why this test is so useful - it allows you to see your biochemistry while there's still time to correct biochemical imbalances. 

              Almost everyone knows someone with cancer, someone who has had cancer, or someone who has died from cancer. We believe that, in today’s world, so many of us are estrogen dominant, or have hormone imbalances, without even knowing.

              Today, there’s so much we can do to detect imbalances early. Based on your test results, you can make more personalise nutrition, environment, and lifestyle choices to better feed, protect, and nurture your DNA hopefully long before you develop symptoms of estrogen excess or an estrogen cancer. Detecting a hormone-driven cancer on a breast, ovarian, or uterine scan might be too late. 

              Who would benefit from this test?

              Anyone with 1 or more of the following:

              • Hormonal imbalances resulting in symptoms and signs of estrogen excess and/or dominance (see list above)
              • Stress, acute or long-term
              • Battling to sleep and you think it might be due to too much stress
              • Signs of estrogen excess or estrogen dominance
              • Considering hormone replacement therapy
              • At-risk of hormone-dependent cancers like breast cancer or prostate cancer 
              • have a risk of hormone-dependent cancers are considering hormone replacement therapy
              • Symptoms of Polycystic Ovarian Syndrome (PCOS)
              • Certain men* might find this test useful - if they have genetic variations that hamper estrogen detox or they are/have been exposed to xenoestrogens in their food and environment. In males, common signs of excess estrogen or problems with estrogen detox include 'moobs' (male boobs), infertility, prostate cancer, and even breast cancer.

                *Men have female hormones, just in smaller amounts. Women have male hormones, just in smaller amounts. 

                More Info



                “This test adds 4 x cortisol readings plus 1 x morning melatonin reading to our 'Hormones & Hormone Metabolites | Small' test. Like estrogen and progesterone, cortisol and melatonin need to always be in balance. Too much cortisol, due to acute or prolonged stress or even the slightest bit of light exposure at night, inhibits the brain's secretion of melatonin. This would've been great to know when we were studying all night, in nightclubs under strobe lights, or up regularly at night tending to our babies in our early 30's!

                Melatonin helps block estrogen receptors so can help prevent estrogen-driven breast cancers. Melatonin is also a powerful antioxidant (yes, 'beauty sleep' is real!) and helps curb carb cravings. It also helps 'turn off' cortisol secretion and thus can reduce stress levels.

                Through our 20's and early 30's, we didn't know about the importance of the cortisol:melatonin ratio. Cortisol is a very empowering hormone - early on, you feel so productive and powerful- it's almost like a drug. It's very easy to deny sleep and be super woman! But after a prolonged time of too much cortisol, your adrenal glands can become depleted of cortisol, like ours did, and the negative effects of adrenal fatigue set in.

                Cortisol is made from progesterone. Sleep and melatonin help preserve your adrenals, your cortisol, and your progesterone. Estrogen and progesterone must also always remain in balance to avoid estrogen dominance. 

                We wish this test had been available from when we were 18 yrs onwards. We believe that knowing our estrogen levels, estrogen:progesterone ratios, and our estrogen metabolites, then taking action to bring these into balance earlier in our lives may have prevented our estrogen-positive cancers. 

                We love that this test measures for possible BPA levels in your body. BPA is a xenoestrogen found in plastic water bottles and polystyrene (think junk food packaging) and can contribute to estrogen excess or estrogen dominance (over progesterone). We've drunk a LOT of water from plastic bottles over our life. I recently did this test, and my BPA levels came back raised - this after I have switched to filling glass bottles with reverse osmosis water. I'm either still exposing my body to an unknown source of BPA or BPA has lasted this long in my body!

                There are things that can be done at every level, from lowering the estrogen burden (better diet, exercise, nutritional supplements, better sleep patterns, etc.) to reducing bad 4-catechol estrogen formation (avoiding pesticides, petrochemicals, etc.), to increasing progesterone if not well balanced with estrogens, to increasing androgens if low (i.e. supplementation with DHEA or testosterone), to using cortisol-lowering vitamins, herbs and melatonin to create balance. There are lots of things that can be done to break the hormonal imbalances we often see in breast cancer patients. One just needs to know what these imbalances are, and this urine test is a best logical approach to finding out what’s “off” and what to do about it. Of course, it would be best to know this info long before a breast cancer diagnosis. This is where prevention really lies".

                Dr Heidi van Loggerenberg

                Benefits | Features

                • Easy to do yourself
                • Simple to do at home
                • Long and stable shelf life of your dried urine sample ensures accurate results
                • Sample doesn't need freezing or any special handling 
                • Highly accurate results
                • Detailed questionnaire included in kit
                • Questionnaire answers incorporated into your personalised report
                • Test takes into account your hormonal stage and adjusts results accordingly
                • Test is relevant for women and men of all ages

                  Tests for

                  A view of the estrogens, progesterones, androgens, male sex hormones, all the estrogen metabolites, and BPA levels. This test adds 4 x cortisol readings over the day/night, plus cortisol metabolites. It also adds 1 x morning melatonin reading.  

                      Test analytes

                      2-Hydroxy Estrone
                      4-Hydroxy Estradiol
                      4-Hydroxy Estrone
                      16α-Hydroxy Estrone
                      2-Methoxy Estrone
                      4-Methoxy Estradiol
                      Bisphenol-A (BPA)
                      Total Cortisol
                      Free Cortisol x 4
                      Total Cortisone
                      Free Cortisone x 4
                      Melatonin (morning)
                      Other Markers:

                      More info about the analytes

                      • Cortisol and its metabolites: This test looks at your diurnal (throughout the day, not just in the morning) cortisol. Assessing your body’s 24-hour cortisol pattern is key to better understanding how your adrenal glands are functioning and helps get to the root of stress-related health issues. Stress plays a huge role in many lifestyle-related chronic diseases. 
                      • Melatonin: This test looks at your morning melatonin level. Melatonin needs to be in balance with cortisol for optimal wellness.
                      • Progesterone and its metabolites. Progesterone needs to be in balance with estrogen to avoid estrogen dominance. Estrogen dominance has been linked to estrogen receptor-positive cancers. Low progesterone can also result after acute or prolong periods of stress. 
                      • Androgens and testosterones: Raised male hormones can convert to estrogen and result in estrogen excess or dominance. Raised male hormones are also involved if you have Polycystic Ovarian Syndrome (PCOS). 
                      • Estrogen and its metabolites: This is more 4-Hydroxy metabolites than any other lab (these are the DNA-damaging estrogen metabolites - you need to know their levels and whether or not you need to take steps to neutralise them).
                      • BPA: Bisphenol A is, among other things, a xenoestrogen. It has been linked to estrogen excess, estrogen dominance, estrogen-positive cancers, and brain, behaviour and health concerns in children and adults. Our lab is one of few labs to include an assessment of BPA in its urine hormone testing.

                      The urine hormone metabolites tests we stock


                      • A view of the main estrogens, progesterones, androgens, male sex hormones, all the estrogen metabolites, and BPA levels.


                        (this test)

                        • A view of the estrogens, progesterones, androgens, male sex hormones, all the estrogen metabolites, and BPA levels. This test adds 4 x cortisol readings over the day/night, plus cortisol metabolites. It also adds 1 x morning melatonin reading.  


                          • A view of the estrogens, progesterones, androgens, male sex hormones, all the metabolites of these hormones, and BPA levels. This test measures 4 cortisol readings over the day/night, plus cortisol metabolites. It also measures 4 melatonin readings over the day/night.  

                          Test comparison table

                          Compare the following tests:

                          Estrogen Elite (our small test), Intermediate (our medium test), Advanced test (our BIG test):

                          Test sample report

                          This is the sample report for the 'Hormones & Hormone Metabolites | Advanced' test. The 'Hormones & Hormone Metabolites | Medium' sample report looks the same but just contains fewer analytes.

                          Sample Test Report: Urine Hormone Metabolites | Advanced test

                          Test instructions

                          Test sample type

                          • Dried urine - dried urine is a form of collection where you saturate a filter card with a urine sample. 

                          Benefits of dried urine testing

                          • Dried urine testing is the best way to measure adrenal and sex steroid hormone by-products and their respective metabolic pathways, providing a gauge for understanding the body’s hormone metabolism
                          • Dried urine method offers a discreet, at-home testing alternative and eliminates the hassles of all-day jug urine collection
                          • You can collect urine on a filter strip up to four times during the day
                          • Dried strips are shelf-stable for 30 days and easy to mail back to the lab for analysis
                          • Once dry, urine cards are extremely stable for shipment and storage
                          • You don’t need to stop hormone supplementation for this test. Our lab has adjusted ranges for age, menstrual status and supplementation types.
                          • This test is the ideal method for tracking the effectiveness of hormone treatments

                            Processing time

                            About 2 weeks

                            Lab's name for test

                            Urinary Hormone Metabolites Intermediate test

                            Lab specs

                            • All tests performed at this laboratory are done to high standards of accuracy
                            • This lab uses state-of-the-art methodology
                            • All tests are validated with internal and/or external controls

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