DNA | Mind + MyPsychRx
"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | firstname.lastname@example.org
This DNA test that incorporates DNA | Mind and mypsychRx into one.
Your DNA holds a wealth of invaluable information about your health and can tell you everything from whether you’re lactose intolerant to if you are at risk for potential DNA damage. Knowing this, it’s absurd to think that we don’t all have an intimate knowledge of our genetic makeup.
DNA | Mind
DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. Weaknesses in these areas, together with environmental factors, increase risk for development of disorders related to mental health. The areas of mental health reported in DNA Mind include: Neurodegenerative disorders, mood disorders, and addictive behaviour.
Mild cognitive impairment (MCI) causes a slight, but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Individuals with mild cognitive impairment are at an increased risk of developing Alzheimer’s Disease (AD) or another dementia. Altered functioning of specific biological areas has been related to increased risk of MCI as well as late-onset AD.
The genes analysed are APOE, CRP, IL-1, IL-6, TNFA, COMT, BDNF which are involved in either lipid metabolism, inflammation, dopaminergic and neurotrophic processes.
Mood disorders are psychological disorders that are characterized by the elevation or lowering of an individual’s mood, to the extent that it can interfere with everyday life for an extended period of time. The specific mood disorders reported include bipolar, depression, anxiety and post-traumatic stress disorder.
The genes associated with mood disorders include CRP, IL-1, IL-6, TNFA, MTHFR, MTR, COMT, BDNF, 1A HTR1A, FKBP5, OXTR, CACNA1C, ANK3, GSK3B and are analysed as part of inflammation, methylation, dopaminergic, neurotrophic, serotonergic, stress response, cell signalling and WNT signalling.
Addictive behaviour can manifest in a number of disorders, which are complex in their aetiology and are influenced by both genetic and environmental factors. Genetics and addictive areas of the association include behavioural disorders such as eating disorders (binge eating), ‘adrenaline seeking’, and risk-taking behaviour. Substance use disorders include risk of alcohol, nicotine, cannabis and opioid dependence. This area will also report on psychosis response from cannabis use.
The genes associated with addictive behaviours are CHRNA3, CHRNA5, CNR1, FAAH, AKT1, DRD1, DRD2, DRD3, DRD4, COMT, OPRM1, BDNF, SLC6A4 and GABRA2. These genes are involved in cell signalling, endocannabinoid, dopaminergic, neurotrophic, serotonergic and stress response processes.
DNA | mygeneRx
Pharmacogenomics, the study of the relationship between genes and response to drugs, has been the subject of intensive research over the past two decades and robust evidence now exists to support testing under clinical conditions.
There is a great deal of variability in how someone responds to medications due to their genes that govern drug metabolism. Pharmacogenomics empowers your doctor to provide person-specific medical interventions and replaces the current trial and error approach to drug therapy.
A pharmacogenomics test gives insight into how specific prescription drugs are metabolised, transported, and bound in your body. This, in turn, allows your doctor to prescribe those medications that will most likely be effective, to avoid those that will not, and to better adjust medication doses to safe, yet therapeutic, levels. Such a personalised approach to medicine has the power to produce better results, particularly for individuals whose genetic profile puts them at risk of experiencing either treatment failure or an adverse reaction from a given drug.
With a deeper knowledge of your genetics, you can ensure you’re taking the right medication, at the right dose. It means fewer side-effects, safer treatment, and maximum efficacy.
"The future of medicine is personalised. Traditionally, the approach to medication has been ‘one dose fits all’. But everyone’s genetic makeup is different. Which means the way you metabolise medication is unique. This can lead to negative side-effects or ineffectiveness of certain medications.By analysing the unique ways your body processes medication and adjusting treatment accordingly, you can increase the effectiveness of your medication. Medical practitioners can also benefit by prescribing treatment that yields better results and avoids a trial and error approach to treating you. This is known as personalised medicine".
What is mypsychRx?
mypsychRx analyses genetic variants linked to the metabolism of key psychotropic medications such as:
- Anti-ADHD agents
- Antidementia agents
- Mood stabilizers
Your mygeneRx Results
Once your mygeneRx cheek swab has been returned to the lab for analysis, and your test analysis in the lab, the results will be sent to you. We encourage you to discuss your results with your doctor so they can plan a safe, informed and effective treatment plan for you.
Note: If your medical practitioner isn’t willing to assist in the process, you should consider getting a second opinion. You have the right to choose a medical practitioner willing to accommodate your unique healthcare needs. We can recommend health care practitioners trained in this test if need be.
It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.
At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.
What are Genes?
Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.
What are Gene Variations?
An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits.
Are Gene Variations Bad?
In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.
Buccal (cheek) lining swab
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