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DNA | Mind

DNALYSIS

R 3,300.00

"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | drheidi@joincircles.com

DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. Weaknesses in these areas, together with environmental factors, increase risk for development of disorders related to mental health. The areas of mental health reported in DNA Mind include: Neurodegenerative disorders, mood disorders, and addictive behaviour.

Neurodegenerative disorders

Mild cognitive impairment (MCI) causes a slight, but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Individuals with mild cognitive impairment are at an increased risk of developing Alzheimer’s Disease (AD) or another dementia. Altered functioning of specific biological areas has been related to increased risk of MCI as well as late-onset AD.

The genes analysed are APOE, CRP, IL-1, IL-6, TNFA, COMT, BDNF which are involved in either lipid metabolism, inflammation, dopaminergic and neurotrophic processes. 

Mood disorders

Mood disorders are psychological disorders that are characterized by the elevation or lowering of an individual’s mood, to the extent that it can interfere with everyday life for an extended period of time. The specific mood disorders reported include bipolar, depression, anxiety and post-traumatic stress disorder.

The genes associated with mood disorders include CRP, IL-1, IL-6, TNFA, MTHFR, MTR, COMT, BDNF, 1A HTR1A, FKBP5, OXTR, CACNA1C, ANK3, GSK3B and are analysed as part of inflammation, methylation, dopaminergic, neurotrophic, serotonergic, stress response, cell signalling and WNT signalling. 

Addictive behaviours

Addictive behaviour can manifest in a number of disorders, which are complex in their aetiology and are influenced by both genetic and environmental factors. Genetics and addictive areas of the association include behavioural disorders such as eating disorders (binge eating), ‘adrenaline seeking’, and risk-taking behaviour. Substance use disorders include risk of alcohol, nicotine, cannabis and opioid dependence. This area will also report on psychosis response from cannabis use.

The genes associated with addictive behaviours are CHRNA3, CHRNA5, CNR1, FAAH, AKT1, DRD1, DRD2, DRD3, DRD4, COMT, OPRM1, BDNF, SLC6A4 and GABRA2. These genes are involved in cell signalling, endocannabinoid, dopaminergic, neurotrophic, serotonergic and stress response processes. 

Benefits of DNA | MIND

Neuropsychiatric disorders account for up to 25% of all disability-adjusted life years (Gatt et al 2015.). Whilst the heritability of these mental disorders is significant, environmental factors also play a key role in their etiology. Genetic variations involved in key biological processes that contribute toward the risk of development of mental health disorders may give insights to the prevention, diagnosis and treatment of the disease.

The DNA Mind test analyses 30 genes which have been shown to have significant associations with key mental health disorders.

Key areas tests

Genes included in the test are involved in key biological areas related to mental health, these include:

  • Lipid metabolism
  • Inflammation
  • Methylation
  • Neurotrophic, dopaminergic and serotonergic pathways
  • Endo-cannabinoid pathway
  • Cell-signalling

Your DNA | MIND results

Once your DNA | MIND cheek swab has been returned to the lab for analysis, and your test analysis in the lab, the results will be sent to you. We encourage you to discuss your results with your doctor so they can plan a safe, informed and effective treatment plan for you.

Note: If your medical practitioner isn’t willing to assist in the process, you should consider getting a second opinion. You have the right to choose a medical practitioner willing to accommodate your unique healthcare needs. We can recommend health care practitioners trained in this test if need be.

Understanding genetics

It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works. 

At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

What are genes

Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

What are gene variations

An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits.  

Are gene variations bad

In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.

Test type

DNA test

Sample required

Buccal (cheek) lining swab

Average processing time

14- 18 days

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