DNA | Health + Estrogen + Diet + Sport + Mind + MyGeneRx
"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | email@example.com
The DNA test that incorporates DNA | Diet, Estrogen, Health, Sport, Mind and mycardioRx, mypainRx, and mypsychRx into one.
DNA | Diet + Estrogen + Health + Sport + Mind Test
We believe that more info is better than less. We believe that more info can be far more useful. Combining* our genetic tests to best suit your needs gives you more info, plus works out more cost effective.
*Due to limited space on this page, please refer to the individual DNA tests (Diet, Estrogen, Health, Sport, Skin, Mind) for more info about each DNA test. The info below is just a summary of each test.
DNA | Health
With a simple swab of your cheek, DNA | Health, a comprehensive DNA test, can help you better understand your health risks and how to prevent them. This test is a great foundation test to combine with one of our other DNA tests.
The 8 key areas that could lead to a chronic illness that this test looks at:
- Lipid Metabolism: High cholesterol potential and whether medication will help reduce raised cholesterol
- DNA Methylation: potential DNA damage risks
- Detoxification: key enzymes needed for effective detoxification
- Inflammation: Inflammation, along with oxidative stress, are 2 key markers for almost all chronic illnesses
- Oxidative stress: this can lead to premature ageing, both inside and outside of your body
- Bone health: Osteoporosis
- Insulin sensitivity: risk of blood sugar and insulin imbalance risks associated with a wide variety including diabetes
- Food responsiveness and sensitivity: lactose intolerance, caffeine processing, salt sensitivity and blood pressure and iron overload disorders
Armed with this invaluable information, you can eliminate future health risks by carefully planning a life-long diet, exercise, supplement and general well-being plan that works to keep at bay the diseases to which you are susceptible.
DNA | Diet
Have you ever followed a diet to the letter and not seen the benefits? The answer to that question is probably yes, as everybody is different, and there is no universal diet that works for everyone.
One of the first products of its kind in the world, DNA | Diet is a test designed to help you manage your weight in a healthy and effective way. It does this by giving you and your healthcare practitioner the information you need to design a personalised weight management plan based on your genetic makeup.
Your genes offer valuable information about how your body reacts to carbohydrates, saturated fats and intensity of exercise, allowing for extreme personalisation of your eating plan to suit your needs.
DNA | Diet tests several well-researched gene variations that impact metabolism, absorption, and storage of fats and carbohydrates, as well as eating behaviour. Research shows that everyone responds differently to different food combinations and there isn’t one correct way of eating for everyone.
With the information gleaned from your DNA | Diet test, you can understand how your body will respond to the three most effective healthy eating plans. i.e. Low Fat, Mediterranean, and Low Carbohydrate. Once we have your results, we will provide a detailed report with recommendations that include dietary changes and an exercise programme.
Benefits of DNA | Diet
- Provides strategies for weight management based on genetic makeup
- Provides motivation for people looking to lose weight
- Provides an understanding of why previous weight-management programs may have been unsuccessful
- Provides insight into which diet type (i.e. Mediterranean-style, low carbohydrate, low-fat diet) may be most suited to you, based on your genotype
DNA | Estrogen
Did you know that approximately 80% of breast cancer occurs in women with no family history? Pretty terrifying, right? Which is why DNA | Estrogen is a test we recommend every woman over the age of 18 should take.
Estrogen affects the function of several target tissues, and research shows that an increased lifetime exposure to estrogen is a strong risk factor for developing breast cancer.
DNA | Estrogen looks for gene variants that have been shown to have an impact on how estrogen is metabolised in your body. The test includes 11 genes involved in estrogen biosynthesis, estrogen metabolism, and phase I and phase II detoxification.
The results of the test provide information to create personalised diet, lifestyle, hormone, and nutraceutical recommendations to improve estrogen metabolism in your body.
This test is beneficial to both men and women who suffer from numerous estrogen-dominant conditions and who have a higher lifetime exposure to estrogens, estrogen metabolites, and other carcinogens.
Benefits of DNA | Estrogen
- Men or women with a strong family history of breast, ovarian, colon or prostate cancer.
- Women who suffer from estrogen-dominant conditions such as endometriosis, premenstrual syndrome and uterine fibroid tumours.
- Women considering oral contraceptives, hormone replacement therapy or bio-identical hormone supplementation.
- Women who are considering in-vitro fertilisation or who have been diagnosed with estrogen receptor-positive breast cancer.
DNA | Sport
Are you an athlete wanting to take your performance to the next level? Then you should seriously consider taking a DNA | Sport test.
There has recently been an explosion in sports genomics research, which has revealed multiple connections between genetic variants and performance success. If you want to fulfil your athletic potential, it is important to make appropriate choices that best match your unique genetic makeup.
Benefits of DNA | Sport
- Structural integrity of soft tissues
- Inflammation & oxidative stress
- Blood flow & respiration
- Energy during exercise
- Fuel during exercise
- Caffeine metabolism
- Muscle & bone composition
- Aerobic capacity
- Power/strength potential
Once you have this information, you can personalise your training programme. This can help you to gain as much as possible from sessions by exploiting potential advantages, as well as to identify weaknesses that need to be worked on. This insight can also be used to make appropriate training and nutrition choices to prevent injury as well as optimise recovery.
DNA | Mind
DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. Weaknesses in these areas, together with environmental factors, increase risk for development of disorders related to mental health. The areas of mental health reported in DNA Mind include: Neurodegenerative disorders, mood disorders, and addictive behaviour.
Mild cognitive impairment (MCI) causes a slight, but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Individuals with mild cognitive impairment are at an increased risk of developing Alzheimer’s Disease (AD) or another dementia. Altered functioning of specific biological areas has been related to increased risk of MCI as well as late-onset AD.
The genes analysed are APOE, CRP, IL-1, IL-6, TNFA, COMT, BDNF which are involved in either lipid metabolism, inflammation, dopaminergic and neurotrophic processes.
Mood disorders are psychological disorders that are characterized by the elevation or lowering of an individual’s mood, to the extent that it can interfere with everyday life for an extended period of time. The specific mood disorders reported include bipolar, depression, anxiety and post-traumatic stress disorder.
The genes associated with mood disorders include CRP, IL-1, IL-6, TNFA, MTHFR, MTR, COMT, BDNF, 1A HTR1A, FKBP5, OXTR, CACNA1C, ANK3, GSK3B and are analysed as part of inflammation, methylation, dopaminergic, neurotrophic, serotonergic, stress response, cell signalling and WNT signalling.
Addictive behaviour can manifest in a number of disorders, which are complex in their aetiology and are influenced by both genetic and environmental factors. Genetics and addictive areas of the association include behavioural disorders such as eating disorders (binge eating), ‘adrenaline seeking’, and risk-taking behaviour. Substance use disorders include risk of alcohol, nicotine, cannabis and opioid dependence. This area will also report on psychosis response from cannabis use.
The genes associated with addictive behaviours are CHRNA3, CHRNA5, CNR1, FAAH, AKT1, DRD1, DRD2, DRD3, DRD4, COMT, OPRM1, BDNF, SLC6A4 and GABRA2. These genes are involved in cell signalling, endocannabinoid, dopaminergic, neurotrophic, serotonergic and stress response processes.
DNA | mygeneRx
The DNA | mygeneRx test analyses your unique DNA to determine how you metabolise medication. DNA | mygeneRx is made up of three separate test panels: mycardioRx, mypainRx, and mypsychRx. You can decide to do each panel separately or all 3 at once.
Pharmacogenomics, the study of the relationship between genes and response to drugs, has been the subject of intensive research over the past two decades and robust evidence now exists to support testing under clinical conditions.
There is a great deal of variability in how someone responds to medications due to their genes that govern drug metabolism. Pharmacogenomics empowers your doctor to provide person-specific medical interventions and replaces the current trial and error approach to drug therapy.
A pharmacogenomics test gives insight into how specific prescription drugs are metabolised, transported, and bound in your body. This, in turn, allows your doctor to prescribe those medications that will most likely be effective, to avoid those that will not, and to better adjust medication doses to safe, yet therapeutic, levels. Such a personalised approach to medicine has the power to produce better results, particularly for individuals whose genetic profile puts them at risk of experiencing either treatment failure or an adverse reaction from a given drug.
With a deeper knowledge of your genetics, you can ensure you’re taking the right medication, at the right dose. It means fewer side-effects, safer treatment, and maximum efficacy.
"The future of medicine is personalised. Traditionally, the approach to medication has been ‘one dose fits all’. But everyone’s genetic makeup is different. Which means the way you metabolise medication is unique. This can lead to negative side-effects or ineffectiveness of certain medications.By analysing the unique ways your body processes medication and adjusting treatment accordingly, you can increase the effectiveness of your medication. Medical practitioners can also benefit by prescribing treatment that yields better results and avoids a trial and error approach to treating you. This is known as personalised medicine".
What is mygeneRx?
mygeneRx harnesses the power of genetic testing to ensure accurate, safe and effective prescription of medication. It’s an easy, non-invasive genetic test that analyses how your body metabolises medication, to highlight what works best for you and your loved ones.
What Does it Test?
mygeneRx analyses genetic variations (genetic misspellings) associated with responsiveness to over 150 medications covering cardiovascular, psychiatry and pain management.
mycardioRx analyses genetic variants linked to the metabolism of common cardiovascular medications such as:
- Angiotensin II receptor antagonists
- Antianginal agents
- Beta blockers
mypsychRx analyses genetic variants linked to the metabolism of key psychotropic medications such as:
- Anti-ADHD agents
- Antidementia agents
- Mood stabilizers
mypainRxanalyses genetic variants linked to the metabolism of key pain medications such as:
- Fibromyalgia agents
- Muscle relaxants
Your mygeneRx Results
Once your mygeneRx cheek swab has been returned to the lab for analysis, and your test analysis in the lab, the results will be sent to you. We encourage you to discuss your results with your doctor so they can plan a safe, informed and effective treatment plan for you.
Note: If your medical practitioner isn’t willing to assist in the process, you should consider getting a second opinion. You have the right to choose a medical practitioner willing to accommodate your unique healthcare needs. We can recommend health care practitioners trained in this test if need be.
It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.
At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.
What are Genes?
Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.
What are Gene Variations?
An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits.
Are Gene Variations Bad?
In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.
- DNA | Health: Gene variations associated with metabolic and biological processes, nutritional genomics, and metabolism.
- DNA | Diet: Gene variations associated with diet, exercise, weight management, metabolism, insulin sensitivity, satiety and feeding behaviour
- DNA| Estrogen: Gene variations associated with a reduced ability to detoxify estrogen, the potential for DNA damage, and a risk from environmental carcinogens including the contraceptive Pill and IVF
- DNA | Sport: Genetic markers for athletic fitness, performance, and injury risk.
- DNA | Mind: DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. mycardioRx: Gene variations associated with the metabolism (breakdown) of common cardiovascular medications (listed in the test sample report below).
- mypainRx: Gene variations associated with the metabolism (breakdown) of common pain management medications (listed in the test sample report below).
- mypsychRx: Gene variations associated with the metabolism (breakdown) of common psychiatry medications (listed in the test sample report below).
Buccal (cheek) lining swab
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