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DNA | Health + Diet + Skin + Sport + Mind

DNALYSIS

R 6,300.00

"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | drheidi@joincircles.com

We believe that more medical info is better than less. Combining our genetic tests to best suit your needs gives you more info plus works out more cost effective.

DNA | Health

DNA | Health is great foundation test to combine with one of our other DNA tests. It can help you better understand your health risks and how to prevent them. 

The 8 key areas that could lead to a chronic illness that this test looks at:

  • Lipid Metabolism: High cholesterol potential and whether medication will help reduce raised cholesterol  
  • DNA Methylation: potential DNA damage risks
  • Detoxification: key enzymes needed for effective detoxification
  • Inflammation: inflammation, along with oxidative stress, are 2 key markers for almost all chronic illnesses
  • Oxidative stress: this can lead to premature ageing, both inside and outside of your body
  • Bone health: Osteoporosis
  • Insulin sensitivity: risk of blood sugar and insulin imbalance risks associated with a wide variety including diabetes
  • Food responsiveness and sensitivity: lactose intolerance, caffeine processing, salt sensitivity and blood pressure and iron overload disorders 

Armed with this invaluable information, you can eliminate future health risks by carefully planning a life-long diet, exercise, supplement and general wellbeing plan that works to keep at bay the diseases to which you are susceptible.

DNA | Diet

Have you ever followed a diet to the letter and not seen the benefits? The answer to that question is probably yes, as everybody is different, and there is no universal diet that works for everyone.

One of the first products of its kind in the world, DNA | Diet is a test designed to help you manage your weight in a healthy and effective way. It does this by giving you and your healthcare practitioner the information you need to design a personalised weight management plan based on your genetic makeup.

Your genes offer valuable information about how your body reacts to carbohydrates, saturated fats and intensity of exercise, allowing for extreme personalisation of your eating plan to suit your needs.

DNA | Diet tests several well-researched gene variations that impact metabolism, absorption and storage of fats and carbohydrates, as well as eating behaviour. Research shows that everyone responds differently to different food combinations and there isn’t one correct way of eating for everyone.

With the information gleaned from your DNA | Diet test, you can understand how your body will respond to the three most effective healthy eating plans. i.e. Low Fat, Mediterranean, and Low Carbohydrate. Once we have your results, we will provide a detailed report with recommendations that include dietary changes and an exercise programme.

Tests for 

Gene variations associated with diet, exercise, weight management, metabolism, insulin sensitivity, satiety and feeding behaviour.

Benefits of DNA | Diet
  • Provides strategies for weight management based on genetic makeup
  • Provides motivation for people looking to lose weight
  • Provides an understanding of why previous weight-management programs may have been unsuccessful
  • Provides insight into which diet type (i.e. Mediterranean-style, low carbohydrate, low-fat diet) may be most suited to you, based on your genotype 

DNA | Skin

DNA | Skin analyses genetic variations on 18 genes associated with key areas involved in skin health and ageing. These are collagen formation, protection from sun and UV exposure, inflammation and protection from oxidative stress. 

Key areas analysed
  1. Sun damage, protection and repair
  2. Sun sensitivity and pigmentation
  3. Firmness and elasticity
  4. Protection from oxidative stress
  5. Detoxification and skin sensitivity
  6. Inflammation

DNA | Sport

Are you an athlete wanting to take your performance to the next level? Then you should seriously consider taking a DNA | Sport test.

There has recently been an explosion in sports genomics research, which has revealed multiple connections between genetic variants and performance success. If you want to fulfil your athletic potential, it is important to make appropriate choices that best match your unique genetic make-up.

Benefits of DNA | Sport
  • The structural integrity of soft tissues
  • Inflammation & oxidative stress
  • Blood flow & respiration
  • Energy during exercise
  • Fuel during exercise
  • Caffeine metabolism
  • Muscle & bone composition
  • Aerobic capacity
  • Power/strength potential

Once you have this information, you can personalise your training programme. This can help you to gain as much as possible from sessions by exploiting potential advantages, as well as to identify weaknesses that need to be worked on. This insight can also be used to make appropriate training and nutrition choices to prevent injury as well as optimise recovery.

Information to optimise

Suitable for the recreational athlete and the elite performance athlete, it provides information to optimise:

  • Power and endurance – physiological factors
  • Structural integrity – tendon pathology and injury risk
  • Recovery – training patterns and nutrition

DNA | Mind

DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. Weaknesses in these areas, together with environmental factors, increase risk for development of disorders related to mental health. The areas of mental health reported in DNA Mind include: Neurodegenerative disorders, mood disorders, and addictive behaviour.

TESTS FOR 
Neurodegenerative disorders

Mild cognitive impairment (MCI) causes a slight, but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Individuals with mild cognitive impairment are at an increased risk of developing Alzheimer’s Disease (AD) or another dementia. Altered functioning of specific biological areas has been related to increased risk of MCI as well as late-onset AD.

The genes analysed are APOE, CRP, IL-1, IL-6, TNFA, COMT, BDNF which are involved in either lipid metabolism, inflammation, dopaminergic and neurotrophic processes. 

Mood disorders

Mood disorders are psychological disorders that are characterized by the elevation or lowering of an individual’s mood, to the extent that it can interfere with everyday life for an extended period of time. The specific mood disorders reported include bipolar, depression, anxiety and post-traumatic stress disorder.

The genes associated with mood disorders include CRP, IL-1, IL-6, TNFA, MTHFR, MTR, COMT, BDNF, 1A HTR1A, FKBP5, OXTR, CACNA1C, ANK3, GSK3B and are analysed as part of inflammation, methylation, dopaminergic, neurotrophic, serotonergic, stress response, cell signalling and WNT signalling. 

Addictive behaviours:

Addictive behaviour can manifest in a number of disorders, which are complex in their aetiology and are influenced by both genetic and environmental factors. Genetics and addictive areas of the association include behavioural disorders such as eating disorders (binge eating), ‘adrenaline seeking’, and risk-taking behaviour. Substance use disorders include risk of alcohol, nicotine, cannabis and opioid dependence. This area will also report on psychosis response from cannabis use.

The genes associated with addictive behaviours are CHRNA3, CHRNA5, CNR1, FAAH, AKT1, DRD1, DRD2, DRD3, DRD4, COMT, OPRM1, BDNF, SLC6A4 and GABRA2. These genes are involved in cell signalling, endocannabinoid, dopaminergic, neurotrophic, serotonergic and stress response processes. 

Sample required 

Buccal (cheek) lining swab - this is just a simple, painless firm rub with a long earbud (the swab) on the inside of your cheek. 

Average processing time 

Around 14 working days  

Sample reports

The science behind these DNA reports

Once the DNAlysis lab receives your DNA sample, they use a process called Polymerase Chain Reaction (PCR) to copy the DNA in your genes many times over, so that they have ample material with which to analyse your genetic material. They then look for unique DNA sequences in your genes, and if they spot changes from the norm, they mark those as risk factors.

Over the years, they have noticed who people that show variations in the gene markers involved in carcinogen metabolism, metabolism of steroid hormones and detoxification, are often part of a subpopulation of women and men with higher lifetime exposure to estrogens, estrogen metabolites and other carcinogens.

By understanding this connection and your unique genetic variability, they can make a holistic assessment of your risks associated with inefficient estrogen detox and provide practical advice on how to reduce these risks.

You can then pair your results with our advanced, home-based hormone metabolites biochemistry tests to measure and track your estrogen detox.

Comment from Dr Heidi

    "We strongly recommend the DNA | Estrogen test for all women and men because we all have estrogen! Yes, women do have more estrogen than men but we all need to know how well we detox estrogen because our world is 'estrogen-ising'.

    Daily, we're all exposed to more and more xenoestrogens from our environment. Xenoestrogens are chemicals that have an estrogen-like effect in the body. They can contribute to estrogen excess and a plethora of signs, symptoms and diseases including cancer.

    Estrogen is referred to as the 'Angel of Life' and 'The Angel of Death'. It is both essential and lethal. It can do so much good yet so much harm. It is important to keep your estrogen in balance with your other sex hormones such as progesterone and testosterone.

    It's also important to ensure that your estrogen detox runs smoothly so your body doesn't generate toxic estrogen metabolites which could cause DNA damage and possibly cancer.

    We would love everyone, especially young women, to do this test. It's a one-off test and you'll have the results for life.

    To get a more comprehensive snapshot of how your body's estrogen detox biochemistry is functioning, consider doing the DNA | Estrogen test (check out the test combo's before deciding on just the DNA | Estrogen test) + a urine hormone metabolites biochemistry test like the DUTCH Test".

    Pair with these biochemistry tests

    Understanding genetics

    It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.

    At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health.

    Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

    What are genes?

    Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

    What are gene variations?

    An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a 'Single Nucleotide Polymorphism', or 'SNP' (pronounced “snip”).

    Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits. 

    Are gene variations bad?

    In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.

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