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DNA | Detox Panel

DNALYSIS

R 1,700.00

"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | drheidi@joincircles.com

We like to look at detox as 'IN' and 'OUT' - 'what goes in' and 'what must come out'. You have a certain amount of control over what comes into your body.

If you know your unique genetic variations for detox, you will know whether your body needs extra support for its detox processes. You can put less pressure on your genes by limiting your toxin exposure PLUS improving your nutritional choices to provide optimal support to your detox genes.

The Detox Panel test can show whether your body has any genetic 'misspellings' ('variations' or 'SNP's') for coding enzymes involved in detox. If you do, you might have signs of imbalances in your biochemistry and symptoms in your body. You can measure and track these biochemical imbalances with a toxicity biochemistry test. 

Pairing a DNA test + toxicity biochemistry test is a great way of getting a lot of good info with which to start creating your personalised detox support protocol.

Benefits

Detoxification is complex. There are many genes that play a role in the cleansing process, and if you have a gene variation in any one of these sequences, your body may need help when it comes to detoxing. The only way to know for sure is through DNA | Health, which will provide you with valuable information such as whether you need to be eating more cruciferous vegetables or taking extra supplements to aid your body’s natural detoxification processes.

Genes analysed

CYP1A1

The cytochrome P450 enzyme converts environmental procarcinogens to reactive intermediates, which are carcinogenic.

GSTM1

Influences Phase II detoxification. It is responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.

GSTP1

Influences the metabolism of many carcinogenic compounds.

GSTT1

A member of a superfamily of proteins that catalyse the conjugation of reduced glutathione.

NQO1

Quinone Reductase is primarily involved in the detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and estrogen metabolism.

Test type

DNA test

Sample required

Buccal/cheek swab

Average processing time

14 -18 days

Understanding genetics

It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.

At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

What are genes

Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

What are genetic variations

An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits. 

Are genetic variations bad

In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology. 

The science behind your report

Once the DNAlysis lab receives your DNA sample, they use a process called Polymerase Chain Reaction (PCR) to copy the DNA in your genes many times over, so that they have ample material with which to analyse your genetic material. They then look for unique DNA sequences in your genes, and if they spot changes from the norm, they mark those as risk factors.

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