DNA | Diet + Skin
"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | email@example.com
Your DNA holds a wealth of invaluable information about your health and can tell you everything from whether you’re lactose intolerant to if you are at risk for potential DNA damage. Knowing this, it’s absurd to think that we don’t all have an intimate knowledge of our genetic makeup.
We believe that more medical info can be far more useful than less. Combining our genetic tests to best suit your needs gives you more info in one go plus works out more cost effective than doing individual panels.
*Due to limited space on this page, please refer to individual DNA tests (Diet, Estrogen, Health, Sport) for more info about each DNA test. The info below is just a summary of each test.
Have you ever followed a diet to the letter and not seen the benefits? The answer to that question is probably yes, as everybody is different, and there is no universal diet that works for everyone.
One of the first products of its kind in the world, DNA | Diet is a test designed to help you manage your weight in a healthy and effective way under the supervision of your healthcare practitioner. It does this by giving you and your healthcare practitioner the information you need to design a personalised weight management plan based on your genetic makeup.
Your genes offer valuable information about how your body reacts to carbohydrates, saturated fats and intensity of exercise, allowing for extreme personalisation of your eating plan to suit your needs.
DNA | Diet tests several well-researched gene variations that impact metabolism, absorption and storage of fats and carbohydrates, as well as eating behaviour. Research shows that everyone responds differently to different food combinations and there isn’t one correct way of eating for everyone.
With the information gleaned from your DNA | Diet test, you can understand how your body will respond to the three most effective healthy eating plans. i.e. Low Fat, Mediterranean, and Low Carbohydrate. Once we have your results, we will provide a detailed report with recommendations that include dietary changes and an exercise programme.
Benefits | Features
- Provides strategies for weight management based on genetic makeup
- Provides motivation for people looking to lose weight
- Provides an understanding of why previous weight-management programs may have been unsuccessful
- Provides insight into which diet type (i.e. Mediterranean style, Low Carbohydrate, Low Fat diet) may be most suited to you, based on your genotype
“Fat storage and being overweight is an established risk factor for many chronic illnesses, including estrogen cancers. Fat creates inflammation and estrogen. Estrogen makes fat. And so the cycle turns itself. Maintaining a normal weight is key to preventing estrogen imbalances, estrogen excess and estrogen cancers.
Over the past 10 years, studies have given insight into the vital role that genes play in a person's weight management. In fact, a genetic disposition is a contributing factor in 40-80% of human body weight variation. This helps explain why not all individuals become obese when exposed to the same food, environment and lifestyle choices and influences.
By understanding your genetics, you can better construct a personalised diet and training program. Imbalances in your sex, adrenal, and thyroid hormones, your hormone metabolites, and your sleep/wake cycles can all play a part in weight gain. Consider doing DNA | Diet, DNA | Estrogen, ZRT's Weight Management test, and a urine hormone metabolite test together, as this may help you to further understand the biochemical reasons for your weight gain or slow weight loss”.
Absorption and Metabolism
- FABP2: Influences fat absorption and metabolism.
- PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids and is also involved in the regulation of glucose and lipid metabolism.
- ADRB2: Involved in the mobilisation of fat from fat cells for energy, in response to catecholamines.
- APOA5: Plays an important role in the regulation of plasma triglycerides.
- ADIPOQ: This gene encodes adiponectin, which is expressed in adipose (fat) tissue. It plays a role in the modulation of a number of metabolic processes, including glucose regulation and fatty acid oxidation.
- UCP1: This gene plays a role in an individual's ability to burn fat.
- UCP2: This gene plays a role in an individual's ability to maintain a healthy BMI.
- UCP3: This gene plays a role in an individual's ability to maintain a healthy BMI.
- ADRB2: This gene plays a role in the mobilisation of fat from fat cells for energy.
- TAS1R2: Believed to contribute to the interindividual variation in sugar consumption.
- SLC2A2 (GLUT2): Influences the first step in glucose-induced insulin secretion, affecting both food intake and regulation.
- DRD2: Midbrain dopamine circuits may play an important role in both addiction and normal eating behaviour as they are involved in reward processing, particularly dopaminergic signalling via dopamine receptor 2 (DRD2).
Fat Metabolism, Obesity and Satiety
- APOA2: An abundant apolipoprotein in HDL. Plays a complex role in lipoprotein metabolism, insulin resistance, obesity and atherosclerosis susceptibility.
Regulation of Metabolism and Feeding Behaviour
- MC4R: A strong obesity candidate gene, significantly associated with energy intake and expenditure.
Regulation of Energy Intake
- FTO: Involved in the regulation of arousal, appetite, temperature, autonomic function and endocrine system.
- TCF7L2: Regulates blood glucose homoeostasis, influencing both insulin secretion and sensitivity.
- ADBR3: Involved in the regulation of lipolysis that influences metabolism.
- CLOCK: An essential regulatory arm of the biological clock, involved in metabolic regulation.
- PLIN: Influences diet-induced obesity.
- TNF-A: TNFα is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole-body glucose homoeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.
Test Sample Report
Overview of our 4 nutrigenomic tests
Pair with these Biochemistry Tests
Order these test to track and measure whether your genetic variations are manifesting in real-time:
DNA | Diet: Gene variations associated with diet, exercise, weight management, metabolism, insulin sensitivity, satiety and feeding behaviour.
Buccal (cheek) lining swab
Average Processing Time
Your DNA holds a wealth of invaluable information about your health and can tell you everything from whether you’re lactose intolerant to if you are at risk for potential DNA damage. Knowing how useful this can be this, we believe we should all have intimate knowledge of our unique genetic makeup.
We believe that more medical info can be more useful than less. Combining our genetic tests to best suit your needs gives you more info in one go, plus works out more cost effective than doing the individual panels.
Armed with this invaluable information, you can begin to eliminate future health risks by carefully planning a personalised life-long diet, exercise, supplement and general well-being plan that works to prevent the diseases to which you most are susceptible.
It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.
At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.
What are Genes?
Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.
What are Gene Variations?
An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits.
Are Gene Variations Bad?
In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.