We've curated every product in our I DO | Nutrition shop based on their nutrigenomic properties and leading manufacturing standards. Nutrigenomics is the study of food and nutrients as one of the most important environmental modifiers of gene expression. A personalised protocol based on your unique DNA, biochemistry and symptoms can help you create optimal wellness and prevent many chronic lifestyle-related diseases. This is called 'personalised scientific wellness'.
CholTrol™ contains artichoke extract and beta-sitosterol that work to support and maintain healthy cholesterol levels.
Pair with these tests
To find out whether you would benefit from this supplement, order one of these tests online:
Luteolin is reported to be an active component of artichoke that reduces hepatic cholesterol synthesis by indirect inhibition of the HMGCoA-reductase enzyme in animal studies. Human studies show a modest reduction in total cholesterol of approximately 18 % after 6 weeks of use. Beta-sitosterol has multiple mechanisms of action: It lowers cholesterol levels by interfering with the intestinal absorption of cholesterol and increasing bile acid secretion. Another mechanism for this effect demonstrated during in vitro studies, is the inhibition of sterol-reductase, an essential enzyme in the process of cholesterol biosynthesis. Beta-sitosterol may interfere with the uptake of micellar cholesterol leading to decreased plasma membrane cholesterol influx and cholesteryl ester secretion. Data indicates that dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism. It has been suggested that plant sterols limit cholesterol ester availability in cells leading to increased degradation of apoB100 (in HepG2 liver cells) and apoB48 (in Caco2 intestinal cells). This would result in the decreased production of VLDL from the liver and chylomicrons from the intestine, precursors of LDL-C and chylomicron remnants, respectively. Beta-sitosterol significantly reduces total and low-density lipoprotein (LDL) cholesterol levels, but has little or no effect on high-density lipoprotein (HDL) cholesterol levels.
Each capsule contains the following active ingredients:
|Artichoke extract (standardised to contains 30 % Luteolin)||100mg|
Inactive ingredients: Magnesium stearate.
Take 1 capsule twice daily with meals.
Do not use this product if you are hypersensitive (allergic) to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Do not exceed recommended dosages unless on the advice of a healthcare practitioner. This medicine has not been evaluated by the Medicines Control Council. This medicine is not intended to diagnose, treat, cure or prevent any disease.
Patients with asthma and kidney disorders must not use CholTrol™ without consulting a doctor. Individuals with a history of gallstones should consult their healthcare practitioner prior to use.
Side effects may include gastrointestinal reactions including slight diarrhoea, abdominal spasm and epigastric complaints like nausea, and heartburn.
Hypersensitivity to the active substance or to plants of the Asteraceae family (Compositae) e.g. daisies and ragweed.
Individuals suffering from bile duct obstruction, cholangitis, gallstones and any other biliary diseases should not use this product.
Patients with hepatitis or sitosterolemia should not use this product.
There are no known interactions.
Pregnancy and Breastfeeding
Safety during pregnancy and whilst breastfeeding has not been established.
Store in a cool dry place below 25°C. Keep out of reach of children.