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TCF7L2

The Transcription factor 7-like 2 gene (TCF7L2) encodes a protein that has been implicated in blood glucose homeostasis (balance). TCF7L2 gene variations are strongly associated with type 2 diabetes and insulin resistance. TCF7L2 genetic variations have also been associated with body mass index (BMI) and cardiometabolic syndrome.

The T-allele indicates an increased risk and therefore should reduce the fat in their diet. A low-fat diet with low GI carbs is best suited to this genotype. 

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