PLIN proteins were discovered in the adipocyte (fat cells), where they regulate lipid storage and lipolysis. This gene's main area of function is the regulation of lipid storage and lipolysis in adipocytes (fat cell). It influences how you lose weight and can result in insulin resistance and poor triglyceride metabolism.
An A-allele genetic variation in this gene can result in reduced perilipin expression, dysregulation in lipid storage and lipolysis in adipocytes. The potential resistance to weight loss resulting in associated obesity, and insulin resistance.