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DNA | Oxidative Stress Panel

 

DNALYSIS

R 1,700.00

"JOINCIRCLES enables you to own your medical data. After buying a DNA test here, we’ll send out your DNA kit on the next working day. When your kit arrives, swab the inside of your cheek and call our courier to collect – follow the simple instructions in the kit. The lab will take around 14 working days to analyse your DNA, from the time they receive your DNA sample. When your results are ready, I'll email them directly to you. To get the full value from your results, we highly recommend that you contact a healthcare practitioner from our ‘Practitioner Circle’ to take you through your results. This will help you understand how and where to focus your efforts. They will also suggest the most relevant blood, blood spot and urine biochemistry tests that you can do going forward, to measure and track your risks and potentials based on your unique genetic variations. After your consult, you could book a wellness coaching appointment with Margie to get you started and keep you on track. Once you have your DNA, you can start shopping personalised nutrition, environment and lifestyle choices on JOINCIRCLES.com. This is how you start on your journey towards optimal wellness! Please contact me if you need help choosing the right test and/or practitioner for your needs". Dr Heidi | drheidi@joincircles.com

Oxidative stress happens when the amount of free radicals exceeds the number of antioxidants. That’s when oxidation damages our cells, proteins and our DNA (genes).

The process of oxidation happens as our bodies metabolise the oxygen that we breathe and our cells produce energy from it. This process also produces free radicals –which interact with the molecules within our cells resulting in damage (or stress) to nearby cells, mitochondria, and DNA (our genes).

Free radicals are normal and necessary to some degree. In addition to causing some damage, they also stimulate repair. It is only when the amount of free radicals produced overwhelms the repair processes that it becomes an issue. That is what we call oxidative stress.

Oxidation happens under a number of circumstances including:

  • when our cells use glucose to make energy
  • when the immune system is fighting off bacteria and creating inflammation
  • when our bodies detoxify pollutants, pesticides, and cigarette smoke
  • when we are physically and/or emotionally stressed 

As long as you have enough antioxidants, a careful balance is maintained and damage is prevented. Antioxidants are oxidant scavengers! They neutralise oxidants so they can't do damage. Antioxidants are found naturally in your body in the form of enzymes plus you can increase your antioxidant intake by eating a wide range of fruit and vegetables. 

The Oxidative Stress DNA Panel can show whether your body has any genetic 'misspellings' ('variations' or 'SNP's') for coding enzymes involved in oxidative stress. If you do, you might have signs of imbalances in your biochemistry and symptoms in your body. You can measure and track these biochemical imbalances with a  biochemistry test. 

Pairing a DNA test + an organic acids biochemistry test is a great way of getting a lot of good info with which to start creating your personalised antioxidant support protocol.

Benefits

Antioxidants are the body’s defence against free radicals. Free radicals can be a normal by-product of the body’s energy processes or can come from the outside in the form of eg. toxins. However, these molecules can damage DNA and proteins in the body and have been linked to various chronic diseases. Antioxidants are found naturally in the body in the form of enzymes, but can also be consumed in a wide variety of foods. DNA | Health will tell you whether you should be altering your diet and lifestyle in order to boost the antioxidant activity in your body.

Genes analysed

ENOS

Influences vascular tone and peripheral vascular resistance. It also has vasoprotective effects by suppressing platelet aggregation, leukocyte adhesion, and smooth muscle cell proliferation.

MNSOD/SOD2

Has vital anti-oxidant activity within the cell, especially within the mitochondria. It destroys the radicals that are normally produced within cells.

CAT

The gene encodes the antioxidant enzyme, catalase. This enzyme is responsible for the rapid conversion of hydrogen peroxide molecules to water and oxygen. Decreased CAT activity can lead to increased oxidative stress.

GPX1

Plays an important antioxidant role in almost every tissue in the body. Genetic variations have been linked to a disturbance in the antioxidant balance with increased risk for chronic disease.

Test type

DNA test

Sample required

Buccal/cheek swab

Average processing time

14 -18 days

Understanding genetics

It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.

At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health. Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

What are genes

Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

What are genetic variations

An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a Single Nucleotide Polymorphism, or SNP (pronounced “snip”). Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits. 

Are genetic variations bad

In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology. 

The science behind your report

Once the DNAlysis lab receives your DNA sample, they use a process called Polymerase Chain Reaction (PCR) to copy the DNA in your genes many times over, so that they have ample material with which to analyse your genetic material. They then look for unique DNA sequences in your genes, and if they spot changes from the norm, they mark those as risk factors.

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