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GSK3B encodes the B-isoform of glycogen synthase kinase 3, which is expressed abundantly in the central nervous system and has been implicated in several neuropsychiatric disorders, including bipolar and major depressive disorder. It is an important target protein of several anti-depressants, including lithium, and upregulation of GSK3B is associated with increased risk for mood disorders.

The GSK3B gene is part of the Wnt signaling pathways which are a group of signal transduction pathways made of glycoproteins that pass signals into a cell through cell surface receptors. The Wnt signaling pathway regulates critical aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development.

A neutral result in this gene means that you have a normal regulation of GSK3B. A medium to high impact variation means that you may have a predisposition to bipolar and depression. 

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