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Fatty acid binding protein 2, encoded by FABP2, is a member of the FABPs; a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. Genetic variations in the gene result in greater binding of the fatty acids, which are released in the intestine from dietary fat consumption, and in turn results in higher absorption of fat.

An A-allele genetic variation is associated with increased fat oxidation, hypertriglyceridemia, increased BMI, hyperinsulinemia and insulin resistance. If you have an A-allele genetic variation in this gene you are at risk for higher levels of LDL-C, and lower levels of HDL-C and therefore you should limit animal-based saturated fat intake and manage total fat intake.


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