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The protein encoded by this gene is involved in the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3). This gene is widely expressed, including in the thyroid, placenta, pituitary, and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site and may contain additional Sec residues. 
 Iodine and selenium are involved in these reactions and may need to be added into your diet if you have a medium to high impact genetic variation in this gene.

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