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APOA2 plays a complex role in lipoprotein metabolism, insulin resistance, obesity, satiety regulation, and atherosclerosis (the build-up of fats, cholesterol and other substances in and on the artery walls) susceptibility.

The C-allele is the variation in this gene that carries the most risk and predisposes you to lower plasma concentrations of ApoA2 as well as being associated with a higher BMI, greater kilojoule intake, and insulin resistance when saturated fat intake is high.

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