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AKT1 encodes one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2, and AKT3) and is important in regulating many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT1 SNPs have been linked to paranoia and psychosis with cannabis use.

Genes encoding proteins involved in cell signalling are important in ensuring normal cell-to-cell communication among nerve cells (neurons), neuronal survival, and the formation of memories. Cell-signalling proteins also serve important roles in activating the release of specific neurotransmitters and hormones.

Calcium and sodium signalling control many neurological functions, including neurotransmitter release and regulation of excitatory signalling in the brain. Disruptions in these pathways have been linked to mood disorders, specifically bipolar disorder.

The AKT1 TC genotype is possibly associated with altered gene function. Individuals with the TC genotype may have a slightly increased risk for paranoia in response to cannabis use.

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